Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead. Josune Orb et. al. Journal of Medicinal Chemistry, 2015, 58(5), pp.2678-2702.

 

Development of Orthogonally Protected Hypusine for Solid-Phase Peptide Synthesis. Aimin Song et. al. The Journal of Organic Chemistry, 2015, 80(7).

 

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design. Christopher R. Butler. Journal of Medicinal Chemistry. 2015, 58(6), pp. 2678-2702.

 

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. Chudi O. Ndubaku et. al. ACS Medicinal Chemistry Letters, 2015.

 

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Sharada Labadie et. al. Bioorganic and Medicinal Chemistry Papers, 2015, 25(1), pp.75-82.

 

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug?Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. Brodney MA et. al. Journal of Medicinal Chemistry. 201558(7), pp. 3223?3252.

 

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked Novel Bacterial Topoisomerase Inhibitors as Broad-Spectrum Antibacterial Agents-SAR of Left-Hand-Side Moiety (Part-2). Sheo B. Singh et. al.  Bioorganic and Medicinal Chemistry,Letters. 2015, 25(9), pp. 1831-1835. 

 

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3). Sheo B. Singh et. al.  Bioorganic and Medicinal Chemistry Letters, 2015 25(12), pp. 2473-2478. 

 

Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4). Sheo B. Singh et. al. Bioorganic and Medicinal Chemistry Letters, 2015, 25(11), pp. 2409?2415.

 

 

Medicinal Chemistry

Emerging Formats for Next-Generation Antibody Drug Conjugates. Mahendra P. Deonarain et. al. Expert Opinion on Drug Discovery, 2015, 10 (5) pp. 463-481.

Identification of Small-Molecule Inhibitors of Calcineurin-NFATc Signaling That Mimic the PxIxIT Motif of Calcineurin Binding Partners. Minos-Timotheos Matsoukas et. al. Science Signal. 2015, 8(382), pp. ra63.

Pharmacological Repression of PPARγ Promotes Osteogenesis. David P. Marciano et. al. Nature Communications, 2015, 6 (7443).

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Daniel Egan et. al. Molecular Cell, 2015.

The Support of Human Genetic Evidence for Approved Drug Indications. Matthew R. Nelson et. al., Nature Genetics, 2015.

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity. Cathy Slack et. al. Cell, 2015, 162, pp. 1–12.

Synthetic Chemistry

Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization, Song Song et. al. ACS Organic Letters, 2015, 17 (12), pp 2886–2889.

Practical Olefin Hydroamination with Nitroarenes. Jinghan Gui et. al. Science, 2015, 348 (6237), pp. 886-891.

Regioselective Metal-Free Cross-Coupling of Quinoline N-Oxides with Boronic Acids. Luis Bering et. al. ACS Organic Letters, 2015, 17 (12), pp 3134–3137.

Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation. Xinxin Shao et. al. Accounts of Chemical Research, 2015, 48 (5), pp 1227–1236.

Practical Olefin Hydroamination with Nitroarenes. Phil S. Baran et. al. Science. 2015, 348(6237), pp. 886-891.