Entries by WuXi AppTec

Medicinal Chemistry When does chemical elaboration induce a ligand to change its binding mode? Malhotra S et al. J Med Chem, 2016, 60(1):128-145. Application of off-rate screening in the identification of novel pan-isoform inhibitors of pyruvate dehydrogenase kinase. Brough PA et al. J Med Chem, 2017, 60(6):2271-2286.Non-coding RNAs as drug targets. Matsui M et al. Nat […]

Solid as a Rock: Creating a Strong Foundation for Developing First-in-Class Treatments to Fight Aggressive Cancers – A Chat with Elaine Sullivan, Co-Founder & CEO, Carrick Therapeutics

By Rich Soll, SVP of Research Service Division at WuXi AppTec (@richsollwx)   In the life sciences, disruptive innovation is no longer the exception; it’s the rule. One global R&D executive known for successfully driving innovation is Elaine Sullivan. Sullivan – who has 25 years of experience in the pharma industry – has led R&D […]

Brave Science: Putting the ‘Hutzpah’ in Early-Stage Drug Discovery – A Chat with Ehud Gazit, Academic Director, Blavatnik Center for Drug Development, Israel

By Rich Soll, SVP of Research Service Division at WuXi AppTec (@richsollwx)   From developing new paradigms for early-stage drug discovery for rare and common diseases to fostering the convergence of peptide nanotechnology, and launching scientific experiments in space, Israeli biochemist Ehud Gazit is wearing many hats these days. In his role as academic director at the newly-formed Blavatnik […]

Harnessing Science for the Most Neglected Diseases – A Chat with Charles Mowbray, Ph.D., Head of Drug Discovery, DNDi

By Rich Soll, SVP of Research Service Division at WuXi AppTec (@richsollwx), December 01, 2016   “Some of these diseases are rapidly fatal, cause huge loss of life, and have a huge impact on people’s lives. Often these are diseases that have attracted little research and attention and certainly haven’t been the focus of traditional […]

Discovery of potent macrocyclic HCV NS5A inhibitors (Source: NCBI) Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742 (Source: NCBI) Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity (Source: NCBI) Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues. (Source: NCBI) Fragment-Based Discovery of a Selective […]

Medicinal Chemistry Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models (Source: NCBI) PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression (Source: NCBI) Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition (Source: NCBI) Targeting BRK-positive breast cancers […]

Medicinal Chemistry G protein-coupled receptors as targets for anti-diabetic therapeutics. (Nature Review Drug Discovery) Late-stage diversification of biologically active molecules via chemoenzymatic  C-H functionalization. (ACS Catalysis) Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.(Nature Medicine) Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. (Science Translational Medicine) […]

Webinar: Tackling the #1 Drug Product Development Problem: Solubility

Date: Thursday, May 5, 2016 Time: 10AM PST | 1PM EST | 6PM GMT Duration: 1 hour Complementary and open to life science professionals globally Overview: Despite significant advances and increased understanding of the importance of physicochemical properties in drugs and drug candidates, solubility is still the number 1 issue in drug product development.  Approximately […]

SDpress April 2016

Innovation That Matters Placing ‘Early’ Bets in Biotech – A Chat With Andy Schwab, Co-Founder & Managing Partner, 5AM Ventures Read full article here Next Generation Immuno-Oncology: Creating a New Pathway to ‘Eat’ Cancer – A Chat with Jonathan MacQuitty, CEO, Forty Seven Read full article here How ‘Cool’ Science Translates Into Successful Companies – […]