Discovery of potent macrocyclic HCV NS5A inhibitors (Source: NCBI)

Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742 (Source: NCBI)

Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity (Source: NCBI)

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues. (Source: NCBI)

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637) (Source: ACS Publication)

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. (Source: NCBI)

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer’s Disease (Source: NCBI)

HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials (Source: NCBI)

Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead. Josune Orb et. al. Journal of Medicinal Chemistry, 2015, 58(5), pp.2678-2702.

 

Development of Orthogonally Protected Hypusine for Solid-Phase Peptide Synthesis. Aimin Song et. al. The Journal of Organic Chemistry, 2015, 80(7).

 

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design. Christopher R. Butler. Journal of Medicinal Chemistry. 2015, 58(6), pp. 2678-2702.

 

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. Chudi O. Ndubaku et. al. ACS Medicinal Chemistry Letters, 2015.

 

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Sharada Labadie et. al. Bioorganic and Medicinal Chemistry Papers, 2015, 25(1), pp.75-82.

 

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug?Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. Brodney MA et. al. Journal of Medicinal Chemistry. 201558(7), pp. 3223?3252.

 

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked Novel Bacterial Topoisomerase Inhibitors as Broad-Spectrum Antibacterial Agents-SAR of Left-Hand-Side Moiety (Part-2). Sheo B. Singh et. al.  Bioorganic and Medicinal Chemistry,Letters. 2015, 25(9), pp. 1831-1835. 

 

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3). Sheo B. Singh et. al.  Bioorganic and Medicinal Chemistry Letters, 2015 25(12), pp. 2473-2478. 

 

Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4). Sheo B. Singh et. al. Bioorganic and Medicinal Chemistry Letters, 2015, 25(11), pp. 2409?2415.