Biology

 

Central Nervous System and Pain 中文 (CN version)


Our CNS/Pain discovery team provides customer-oriented services with our AAALAC accredited animal facility and world class laboratories including GLP standard lab.

In Vitro and Ex Vivo Assays

  • Ex vivo assays for receptor occupancy, brain slice with functional readout and neuronal recordings (isolated brain cell recordings)
  • Assay development, screening and SAR support for related GPCRs, transporters and ion channels
  • Cell line development
  • e-phys assays automated patch clamp, manual patch clamp
  • GLP-certified hERG test (best in China)

In Vivo Models

  • Schizophrenia: Prepulse inhibition of startle (PPI), conditioned avoidance response (CAR), Morris water maze,delayed alternation task (Y-maze),novel object recognition (NOR), attentional set shifting
  • Neurodegenerative diseases (e.g. AD & PD):Scopolamine induced cognitive deficits, 6-OHDA unilateral lesion model; L-DOPA induced dyskinesia in 6-OHDA PD rats, HIC (haloperidol induced catalepsy)
  • Anxiety & depression: Vogel conflict test, open field (sLMA, cognition and anxiety), elevated plus maze, forced swimming test, learned helplessness

Translational Science for Neurodegenerative Diseases and Neuropathic Pain

  • PK/PD for target engagement and MOA, biomarkers, chemical, CSF, in vivo e-phys, EEG (in development), safety pharmacology, Irwin test for general neurological liabilities

Correlation of in vivo receptor occupancy with behavior readout

BIO-CNYP3